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Past Meetings - Notes and Presentations
2007-2008 LAM/TSC Seminar Series
June 5, 2008
“The VHL Tumor Suppressor Protein: Cancer and Oxygen Sensing”
Speaker: William Kaelin, MD (DFCI/HMS)
Discussant: Leif Ellisen, MD, PhD (MGH Cancer Center/HMS)
May 29, 2008
“TSC2 and glucose transport: Implications for treating LAM and TSC "
Speaker: Ray Yeung, MD, FRCS (C), FACS (University of Washington)
Discussant: Lewis Cantley, PhD (BIDMC/HMS)
APRIL 17, 2008
"Development of novel PI3 Kinase and MTOR Inhibitor"
Speaker: William Sellers, MD (Novartis)
Discussant:
Matthew Kulke, MD (DFCI/HMS)
March 13, 2008
“Melanocytic markers in non-melanoma malignancies: Role of the MiT transcription factor” & “Why do LAM Cells express melanocytic markers?”
Speakers: David Fisher, MD, PhD (MGH/HMS) & Elizabeth Henske, MD (FCCC)
Discussant:
Andrew Wagner, MD, PhD (DFCI/HMS)
February 28, 2008
"Molecular mechanisms and the genetics underlying the pathogenesis of human cancer."
Speaker: Pier Paolo Pandolfi, MD, PhD (BIDMC/HMS)
Discussants:
Elizabeth Thiele, MD, PhD (Massachusetts General Hospital/HMS)
Brendan Manning, PhD (Harvard School of Public Health)
January 24, 2008
"Critical re-cap of this week's NCI/NIH-NINDS mTOR workshop & Review of NEJM articles & letters re: LAM & TSC"
Speakers: Mustafa Sahin, MD, PhD; Vijaya Ramesh, PhD; David Kwiatkowski, MD, PhD; Sandra Dabora, MD, PhD; Elizabeth Thiele, MD, PhD; Po-Shun Lee, MD; Geraldine Finlay, MD
November 1, 2007
““Lymphangiogenesis: the state of the art and translational medicine; & “Lymphangiogenesis and Hormonal modulation in LAM”
Stan Rockson, MD
Kuniaki Seyama MD, PhD
Joel Moss MD, PhD
October 11, 2007
Dr. Brendan Manning, PhD
"Rewiring and misfiring: Signaling defects triggered by loss of the TSC tumor suppressors"
http://www.hsph.harvard.edu/faculty/brendan-manning/
September 20th, 2007
Dr. Joseph Avruch, MD, PhD
Dr. John Blenis, PhD
"Regulation of cell growth and protein synthesis by mTOR"
2006-2007 LAM/TSC Seminar Series
June 21 , 2007
Dr. Geraldine Finlay, MD
Dr. Vijaya Ramesh, PhD
"Statins: Therapeutic agents for TSC2 null states"
"MED28 (magicin) Functions as a Transcriptional Repressor of Smooth Muscle Differentiation at the Stem Cell Level: Implications for LAM and Other Smooth Muscle Tumors"
May 10 , 2007
Dr. M Celeste Simon, PhD
Dr. Leif Ellisen, MD, PhD
"Hypoxia, Stem Cells, and Tumor Progression"
by Dr. Simon
"Hypoxia regulation of TSC/mTOR signaling"
by Dr. Ellisen
April 12 , 2007
Elizabeth Henske, MD
Elizabeth Thiele, MD
Elahna Paul, MD, PhD
Stuart Silverman, MD
Special Panel: Renal AMLs in LAM/TSC
"What can basic science teach us about improved clinical care?"
"What can diagnostic dilemmas teach us about the basic science of LAM/TSC?"
March 15 , 2007
Dr. Peter Crino, MD, PhD
Dr. David Louis, MD
"New Developments in the Neurobiology of the Tuberous Sclerosis Complex" by Peter Crino and "Molecular Insights into the Effects of Therapy on Malignant Gliomas"by David Louis
February 1 , 2007
Dr. Cheryl Walker, MD
Dr. Kwiatkowski, MD, PhD
"New Therapeutic Targets for Combination Therapy with Rapamycin in TSC and LAM"
January 18 , 2007
Dr. Lew Cantley, MD
"mTOR dependent regulation of growth and metabolism: Implications for the treatment of LAM/TSC"
Dr Cantley's Powerpoint Presentation
December 14 , 2006
Dr. Lisa Henske, MD
"Does Estrogen Synthesize with mTOR activation to promote LAM cell metastasis? "
Dr Henske's Powerpoint Presentation
November 30, 2006
Dr. Joel Moss
Dr. Myles Brown
Dr. George Demetri
"LAM Research: New Insights & Unanswered Questions"
Dr. Joel Moss (NIH-NHLBI) discussed key challenges in research on Lymphangioleiomyomatosis (LAM). Dr Myles Brown and Dr. George Demetri discussed and facilitated exchange on topics and potential therapeutic interventions.
October 26, 2006
Dr. David Sabatini
Dr. Brendan Manning
"mTOR Function and Regulation: Implications for the treatment of Lymphangioleiomyomatosis (LAM) & Tuberous Sclerosis Complex (TSC)"
Dr. David Sabatini is Associate Professor of Biology at MIT. Dr. Brendan Manning is Associate Professor of Genetics and Complex Disease at the Harvard School of Public Health.
Brendan Manning's Powerpoint Presentation
David Sabatini's Powerpoint Presentation
2005-2006 LAM/TSC Seminar Series
June 22 , 2006
Kun-Liang Guan, Ph.D.
Lew Cantley, Ph.D
Kun-Liang Guan, Ph.D. from the University of Michigan whose work on signaling biochemistry and TSC1/TSC2 is highly relevant to LAM/TSC will present.
Lew Cantley, Ph.D (BIDMC, HMS) who has done seminal work on P13Kinase and protein kinase signaling pathways is highly relevant to these diseases will serve as discussant and moderator.
Dr. Miles Brown, MD
Dr. David Kwiatkowski, MD, PhD
"LAM is a disease that mainly affects women. This seminar will focus on the links between estrogen and LAM. "
Myles Brown, MD (Dana-Farber/HMS) will speak about his work on estrogen in cancer and LAM.
David Kwiatkowski, MD, PhD. (BWH/Dana-Farber/HMS) will review data on estrogen in mouse models and LAM and some new results from mutational studies of TSC1/TSC2.
Dr. Frances Jensen, MD
Dr. Vijaya Remesh, PhD
"Cell-specific abnormalities in neurotransmitter receptor expression in TS lesions and Regulations of TSC proteins in the CNS "
Dr. Jensen is a Senior Associate in Medicine at Children's Hospital Boston and Associate Professor of Neurology, Harvard Medical School Dr. Ramesh is an Assistant in Genetics, Molecular Genetics Unit MGH and Associate Professor, Dept. of Neurology HMS.
Dr. Bernardo Sabatini, MD, PhD
Dr. Elizabeth Thiele MD, PhD
"Tuberous Sclerosis Complex and the Brain "
Dr Thiele spoke about the neurologic involvement in TSC followed by a talk on the basic science by Dr. Sabatini, who will also facilitated discussion.
Dr. Frank McCormack
"Current and future trials of mTOR inhibitors in patients with TSC and LAM "
Director, Division of Pulmonary and Critical Care at the University of Cincinnati and Chair of the LAM Foundation Scientific Advisory Board
Dr. Judah Folkman
Dr. Marsha Moses
"Can lessons from antiangiogenic therapy of cancer be applied to LAM?"
Dr. Folkman spoke about his recent work on LAM with Dr. Marsha Moses, Associate Professor of the Department of Surgery at Harvard Medical School / Vascular Biology Program at Children's Hospital Boston
Dr. Joe Avruch
Professor at Harvard Medical School
Dr. Avruch spoke about his work on kinase signaling pathways and recent results on the Rheb-mTOR interaction.
